magnesium sulfate effect on the clinical course and gcs of patients with a severe diffuse axonal injury

based on a number of studies, magnesium sulfate (mgso4) given after a diffuse axonal injury has gained attention as a useful neuroprotective agent .the present study was conducted to examine if magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. adult patients admitted within 1 hour of a closed traumatic brain injury (tbi) with a severe diffuse axonal injury that met eligibility criteria were randomized into two groups. our treatment guidelines consisted of an initial loading dose of 50 mg/kg magnesium sulfate and then 50 mg/kg qid up to 24 hours after the trauma. the outcome measures were mortality, gcs, and motor function scores which were assessed up to 2 months after the trauma. magnesium showed a significant positive effect on gcs 2 months (p=0.03).  among those in mgso4 group, motor functioning score improved more than control group but this was not statistically significant (p = 0.51). at the end, we have demonstrated that administration of magnesium sulfate can have neuroprotective role following severe dai.